The problem of drug therapy (DTP) is any unwanted incident related to drug therapy that actually or potentially affects the desired goals of treatment. Patients with heart failure (HF) are more likely to experience DTP due to multiple prescriptions and comorbidities. Data collectors participated in medical room rounds to document each drug treatment, and each patient's compliance with prescribed drug therapy was assessed through semi-structured interviews. The need for additional drug treatment was the main DTP identified in the study, accounting for 25.2%, and this was similar to the study conducted in four French-speaking countries and 5 paediatric clinics in Greece, which explained that additional drug requirements were the most common DTP with 25% and 28%, respectively.
Drug therapy problems related to the indication may be “unnecessary drug therapy” or “need for additional drug therapy”. Finally, a relatively large number of pharmacotherapy problems remain unresolved, owing to the unavailability of some recommended drugs and the inability of patients to afford research and drug costs. Antibiotics were the main class of drugs involved in the drug therapy problem and, among the risk factors evaluated, errors in prescribing and calculating the dose showed statistical significance. Ceftriaxone (25.81%) was the most common specific drug prone to drug treatment problems, followed by spiranolactone (14.52%), enalapril (6.45%) and furosemide (6.45%).
It is a DTP that occurs when the dose is too low to produce the desired result, or the dosage interval is too infrequent, or a drug interaction reduces the amount of active drug available or the duration of therapy is too short. Antibiotics, 75 (40.32%) were the most common drug class involved in pharmacotherapy problems, followed by cardiovascular drugs, 69 (37.1%) and non-steroidal anti-inflammatory drugs, 9 (4.84%). Secondary objectives included assessing intrarater reliability between investigators' severity ratings and assessing the likelihood of adverse drug reaction damage by drug classes. The problem of drug therapy (DTP) is any undesirable event experienced by a patient related to drug therapy that interferes with the achievement of the desired goals of therapy.
Of the 159 DTP, additional pharmacotherapy needs were the most common pharmacotherapy problem identified accounting, 57 (35.85%). This can also be described by prescribing drugs for cases that are self-limited and for those who do not need drug treatment at the time of prescription and the prescribed drug that is inappropriate for the compilation indication, since all these conditions cause the appearance of DTP. Occurrence of classes and mean score of probability of harm, in drug therapy problems classified as adverse drug reactions. Requirements for additional drugs was the most predominantly drug therapy problem encountered (30 (25.2%)).
Drug-related problems fall into seven categories, which are unnecessary drug therapy, need for additional medications, ineffective drugs, too low dose, too high dose, adverse drug reaction, and non-compliance.